| Methods |
Randomized trial
Study period: not given |
| Participants |
Inclusion criteria: women with postpartum endometritis based on 2 temperatures of more than 38.6 °C at least 4 hours apart or a single temperature of more than 38.6 °C during the first 24 hours after delivery; uterine tenderness; and no other apparent source of fever
Setting: Medical College of VIrgina Hospitals, Richmond, Virginia, USA
Number of participants: n = 81 |
| Interventions |
Ceftizoxime 2 g iv every 12 hours (n = 43) vs cefoxitin 2 g every 6 hours (n = 38) |
| Outcomes |
Treatment failure
Complications including phlebitis, wound infection, allergic reactions, and diarrhea |
| Notes |
Cesarean births could have received cefazolin antibiotic prophylaxis during surgery (n = 73)
Vaginal births (n = 8)
Pharmaceutical sponsorship ‐ explicit |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
States “Patients were randomly assigned” no further description |
| Allocation concealment (selection bias) |
Unclear risk |
Not stated |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
States “Double blinded” ”physicians did not know which antibiotic was being used.” |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
States ”physicians did not know which antibiotic was being used.” |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
Drop‐outs unclear |
| Selective reporting (reporting bias) |
Unclear risk |
The protocol is not available, insufficient information to permit judgment |
| Other bias |
High risk |
Pharmaceutical sponsorship ‐ evident |
