Summary of findings for the main comparison. Rutoside compared with placebo for varicose veins and leg oedema in pregnancy.
| Rutoside compared with placebo for varicose veins and leg oedema in pregnancy | ||||||
| Patient or population: Pregnant women with varicose veins and leg oedema in pregnancy Settings: Netherlands Intervention: Rutoside Comparison: Placebo | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| placebo | Rutoside | |||||
| Woman's perception of pain (as defined by trialists) | This outcome was not reported by this included study. | |||||
| Complications associated with varicose veins and leg oedema (deep vein thrombosis) | Study population | RR 0.17 (0.01 to 3.49) |
69 (1 RCT) |
⊕⊕⊕⊝ MODERATE 1 | ||
| 63 per 1000 | 11 per 1000 (1 to 218) |
|||||
| Symptoms associated with varicose veins and oedema (improvement in symptoms) | Study population | RR 1.89 (1.11 to 3.22) | 69 (1 RCT) | ⊕⊕⊕⊝ MODERATE 1 | ||
| 344 per 1000 | 650 per 1000 (382 to 1000) | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: risk ratio | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1One study of small sample size