Summary of findings for the main comparison. Rutoside compared with placebo for varicose veins and leg oedema in pregnancy.
Rutoside compared with placebo for varicose veins and leg oedema in pregnancy | ||||||
Patient or population: Pregnant women with varicose veins and leg oedema in pregnancy Settings: Netherlands Intervention: Rutoside Comparison: Placebo | ||||||
Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
Assumed risk | Corresponding risk | |||||
placebo | Rutoside | |||||
Woman's perception of pain (as defined by trialists) | This outcome was not reported by this included study. | |||||
Complications associated with varicose veins and leg oedema (deep vein thrombosis) | Study population | RR 0.17 (0.01 to 3.49) |
69 (1 RCT) |
⊕⊕⊕⊝ MODERATE 1 | ||
63 per 1000 | 11 per 1000 (1 to 218) |
|||||
Symptoms associated with varicose veins and oedema (improvement in symptoms) | Study population | RR 1.89 (1.11 to 3.22) | 69 (1 RCT) | ⊕⊕⊕⊝ MODERATE 1 | ||
344 per 1000 | 650 per 1000 (382 to 1000) | |||||
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: risk ratio | ||||||
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. |
1One study of small sample size