Marhic 1991.

Methods	Randomised controlled trial comparing 4 g of troxerutin (Hydroxyethylrutoside) in 2 doses with a placebo.
Participants	Inclusion criteria: pregnant women in their second trimester with symptomatic vulvar varicosities and venous insufficiency in their lower extremities. Exclusion criteria: none stated.
Interventions	intervention group: 4 g of troxerutin (Hydroxyethylrutoside) in 2 doses. Comparision group: placebo. Study duration: 4 months.
Outcomes	Pain and discomfort from vulvar varicosities. Pain due to limb venous insufficiency. Heaveness in the legs.
Notes	The trial examined the efficacy of troxerutin in gynaecology and obstetric. In this review, only information about obstetric populations was included. Data not in useable format. Not able to trace the authors. Sample size: 30 women. Country: France. Study years: not stated.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Sequence generation not described.
Allocation concealment (selection bias)	Unclear risk	Allocation concealment not described.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Study described as double blind.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blinding of outcome assessor not described.
Incomplete outcome data (attrition bias) All outcomes	Low risk	30 women randomised. Data for all women presented.
Selective reporting (reporting bias)	Low risk	Selective reporting not apparent.
Other bias	Low risk	None noted.