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. Author manuscript; available in PMC: 2020 Mar 2.
Published in final edited form as: J Med Chem. 2019 Oct 11;62(20):9236–9245. doi: 10.1021/acs.jmedchem.9b01147

Figure 5.

Figure 5.

Therapeutic effect of 1a. (a) Luminescence images of mice harboring U87-RFP-Luc subcutaneuous tumors and treated with indicated compounds were acquired with an IVIS Spectrum in vivo imaging system (PerkinElmer) at 2 and 5 weeks after drug administration. (b) Mean tumor size (cm2) with SEM over a 5-week period after drug administration (n = 3). Two-way ANOVA with Bonferroni posttest shows statistically significant differences between 1a or gem compared with vehicle control group at 4 weeks (**p < 0.01) and 5 weeks (***p < 0.001). (c) Mean tumor luminescence (photons per second, p/s) with SEM over a week period (n = 3). Two-way ANOVA with Bonferroni posttest shows statistically significant differences between 1a or gem and the vehicle group at 5 weeks (p < 0.001).