Figure 6.

Localization/clearance of 1a in vivo. (a) Mice were injected with 10 mg/kg 1a with an uninjected control (last mouse in each view). Images were taken at 0.5, 1, 2, 24, 48, and 144 h after intravenous injection, and their fluorescence intensities are normalized to be on the same scale. (b) Images at 10× lower scale show persistence of fluorescence in 1a-treated mice, indicating residual drug localization over extended periods.