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. 2020 Jan 17;141(9):751–767. doi: 10.1161/CIRCULATIONAHA.119.042559

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© 2020 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 7. — Mechanistic overview. Proposed therapeutic mode of action for the antifibrotic compounds bufalin and lycorine in angiotensin II–mediated diastolic dysfunction. Treatment with the lead natural compound results in a decline in microRNA (miR) 671-5p levels in cardiac fibroblasts, which, in turn, leads to derepression of its target selenoprotein P1 (SEPP1). LV indicates left ventricular.