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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Cancer Res. 2019 Nov 8;80(2):334–346. doi: 10.1158/0008-5472.CAN-19-1161

Figure 6. Knockdown of COASY induces radiosensitization of CRC in vivo.

Figure 6.

A) Experimental design: NSG mice underwent subcutaneous flank injection with RKONT, RKOshRNA#1, or RKOshRNA#2. When tumors reached approximatively 200 mm3, mice received radiation with 2 Gy using X-beam at 1 Gy/min per day during 5 consecutive days (arrows). B) Tumor growth was monitored in control condition (left panel) or treated with irradiation (right panel) every two days using calipers. Data are represented as mean ± SE (n=3 for control and n=4 for both shRNA groups). Representative images of harvested tumors on day 8 for control and day 21 for tumor treated with irradiation are shown. C) Ki67 immunofluorescence staining on tumors harvested on day 21. Representative pictures of each xenograft cell line are shown. D) Cleaved caspase-3 immunofluorescence staining on tumors harvested on day 21. Representative pictures of each xenograft cell line are shown.