Figure 2.

Cerebral edema in patients with cirrhosis. The first report of cerebral edema and severe intracranial hypertension in patients with sepsis with cirrhosis after placement of TIPSs. The x axis depicts the time since insertion of transjugular intrahepatic stent‐shunt; the y axis shows the intracranial pressure (in mm Hg). These data first led to the idea that a patient with cirrhosis can manifest the cardinal sign of ALF, giving birth to the idea that a new syndrome, ACLF, may exist. Data are from Jalan et al.20