Table 1.

Chronology of Development of the Idea and Organizational Activity in ACLF Worldwide

1997	Jalan R et al. Elevation of intracranial pressure following transjugular intra‐hepatic portosystemic stent‐shunt for variceal haemorrhage. J Hepatol 1997;27:928‐933
2002	Jalan R, Williams R. Acute‐on‐chronic liver failure: Pathophysiological basis of therapeutic options. Blood Purif 2002;20:252‐261
2003	“Towards Defining ACLF” meeting at AASLD—Blei, Arroyo, Kamath, Garcia‐Tsao, Jalan and Williams; plans for ICLFSG shelved
2004	“Prospects for Liver Support” (University College London)
	Concept of ACLF gaining acceptance
	Jalan R, Sen S, Williams R. Prospects for extracorporeal liver support. Gut 2004;53:890‐898
2007	EASL‐CLIF Consortium
	First prospective study specifically to define ACLF started in 2009
2009	APASL
	First consensus definition of ACLF
2012	Publication of the first comprehensive review detailing pathophysiology: Jalan R, et al. J Hepatol 2012;57:1336‐1348
2013	Publication of the CANONIC study: Moreau R, et al. Gastroenterology 2013;144:1426‐1437
2014	Publication of the CLIF‐C ACLF score: Jalan R, et al. J Hepatol 2014;61:1038‐1047
2014	NACSELD established