Table 2.

Variations in Definitions of ACLF Worldwide

	Consortium
	APASL	EASL‐CLIF	NACSELD	WGO
Diagnostic parameters	Acute jaundice and coagulopathy, followed by ascites ± HE <4 weeks in undiagnosed or diagnosed chronic liver disease, including cirrhosis	Specified criteria using CLIF‐OF score(s) for OF, 28‐day mortality rate >15% from AD of cirrhosis, without/with prior decompensation often caused by infection	Specified criteria for ≥2 OFs in patients with infection, at or during admission	Acute hepatic decompensation resulting in jaundice, elevated INR, and ≥1 or more OFs, with increased mortality in 28‐90 days, with or without previously diagnosed cirrhosis
Exclusion criteria	Bacterial infection or previous AD	Patients admitted electively for procedures or therapy, or those with hepatocellular carcinoma outside Milan criteria, or receiving immunosuppressive therapy, with HIV or with severe chronic extrahepatic disease	Outpatients with infection, any patient with HIV infection, prior organ transplants, or disseminated malignancies	None stated