Figure 6:

Radiomic-Pathomic-Genomic association. a) CT scan f) corresponding whole-slide tissue scan i) corresponding mRNA sequencing data. b) Intratumoral and c) Peritumoral Radiomic Haralick textural feature for low-risk nodule with g) representation of SpaTIL feature on corresponding whole-slide scan. d) and e) represents intratumoral and peritumoral Haralick feature for high-risk nodule with h) corresponding SpaTIL representation. QuRiS predicted high risk patients had a more chaotic and disturbed microarchitecture observed on CT scans. For these patients, the corresponding whole slide tissue images revealed very dense, tightly bound cancer nuclear clusters. j) represents corresponding gene set enrichment analysis for these patients. On genomic level, QuRiS was observed to have correlation with chemotaxis.