Table 2.

Clinical Characteristics of Breakthrough Invasive Fungal Infection Episodes

Characteristics	No. 1	No. 2	No. 3	No. 4	No. 5	No. 6	No. 7	No. 8
Types of IFI	IA	IA	IA	IA	Candidemia	Candidemia	Trichosporosis	IA
Age (years)	28	59	63	41	61	43	26	28
Sex	Male	Male	Male	Male	Female	Male	Male	Male
Episode	AML, induction	AML, GVHD	MDS, GVHD	Lymphoma, alloSCT	AML, induction	AML, GVHD	AA, alloSCT	AML, induction
Days of prophylaxis until the diagnosis of IFIs	25	4	35	13	3	29	13	23
Positive BDG in serum	No	Yes	Yes	No	No	Yes	No	Yes
Fungal culture	Not done	Not done	Sputum, no growth	Sputum, no growth	Blood, growth	Blood, growth	Blood, growth	Not done
Timing of CT scan (before or after BDG)	Before	Before	Before	After	Before	Not performed	After	After
Image findings	Cavitary lung nodule in CT	Cavitary lung nodule in CT	Multiple lung nodules in CT	Multiple cavitary nodules in CT	-	-	Multiple lung nodules in CT	Cavitary lung nodule in CT
Length of hospitalization	77	24	98	53	75	30	95	41
Outcome	Alive	Alive	Alive	Alive	Alive	Dead	Alive	Alive

Abbreviations: AA, aplastic anemia; alloSCT, allogeneic stem cell transplantation; AML, acute myelogenous leukemia; BDG, β-d-glucan; CT, computed tomography; GVHD, graft-versus-host disease; IA, invasive aspergillosis; IFI, invasive fungal infection; MDS, myelodysplastic syndrome.