Table 4.
Diagnostic Values of β-d-Glucan for Subgroups Defined by Test Numbers and Antimold Agents
| Characteristics | Overall (n = 141) | Subgroups According to the Numbers of BDG Tests | Subgroups According to Antimold Agents | |||
|---|---|---|---|---|---|---|
| ≥2 (n = 109) | ≥3 (n = 78) | ≥4 (n = 53) | Micafungin (n = 78) | Posaconazole (n = 63) | ||
| TP, n (%) | 4 (2.8) | 4 (3.7) | 4 (5.1) | 3 (5.7) | 0 (0.0) | 4 (6.3) |
| FN, n (%) | 4 (2.8) | 3 (2.8) | 3 (3.8) | 3 (5.7) | 2 (2.6) | 2 (3.2) |
| TN, n (%) | 112 (79.4) | 81 (74.3) | 51 (65.4) | 33 (62.3) | 71 (91.0) | 41 (65.1) |
| FP, n (%) | 21 (14.9) | 21 (19.3) | 20 (25.6) | 14 (26.4) | 5 (6.4) | 16 (25.4) |
| Sensitivity, % (95% CI) | 50.0 (15.7–84.3) | 57.1 (18.4–90.1) | 57.1 (18.4–90.1) | 50.0 (11.8–88.2) | 0.0 (0.0–84.2) | 66.7 (22.3–95.7) |
| Specificity, % (95% CI) | 84.2 (76.9–90.0) | 79.4 (70.3–86.8) | 71.8 (59.9–81.9) | 70.2 (55.1–82.7) | 93.4 (85.3–97.8) | 71.9 (58.5–83.0) |
| PPV, % (95% CI) | 16.1 (8.0–29.8) | 16.0 (8.3–28.6) | 16.7 (8.7–29.6) | 17.6 (7.9–34.8) | 0.0 (NA) | 20.0 (11.0–33.5) |
| NPV, % (95% CI) | 96.5 (93.3–98.2) | 96.4 (92.0–98.5) | 94.4 (87.7–97.6) | 91.7 (82.9–96.2) | 97.3 (97.1–97.4) | 95.3 (86.8–98.5) |
Abbreviations: BDG, β-d-glucan; CI, confidence interval; FN, false negative; FP, false positive; NA, not applicable; NPV, negative predictive value; PPV, positive predictive value; TN, true negative; TP, true positive.