Table 4.
Top upstream regulators activated in hMDMs after infection with mycobacteria with respect to 19 potential DEGs.
| Upstream regulator | p-Value of overlap | Predicted activation |
|---|---|---|
| IFNL1 | 4.33E-26 | Activated |
| TLR3 | 5.86E-25 | Activated |
| IFN-β | 1.56E-23 | Activated |
| TLR9 | 4.68E-23 | Activated |
| TLR7 | 4.81E-23 | Activated |
Abbreviations: hMDMs, human monocyte derived macrophages; DEGs, differentially expressed genes; IFNL, interferon ligand; TLR, toll like receptor. The data were analyzed through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis).