Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Strain, strain background (Escherichia coli)	BL21(DE3)	Sigma-Aldrich	CMC0016	Electrocompetent cells
Recombinant DNA reagent	pBV-Luc-c36 (plasmid)	This paper		IPTG inducible Were-1–controlled firefly luciferase gene with T7 RNA polymerase promoter
Recombinant DNA reagent	pBV-Luc (plasmid)	Adgene	RRID: Addgene_16539	Parent plasmid for Were-1 construct
Chemical compound, drug	Amino-tSS	This paper		Were-1 ligand, trans isoform
Chemical compound, drug	Amino-cSS	This paper		Cis isoform of the Were-1 ligand
Chemical compound, drug	tSS	This paper		Were-1 ligand, trans isoform lacking a linker
Chemical compound, drug	tS	Sigma-Aldrich	Cat# 139939	Trans stilbene
Chemical compound, drug	tDHS	Santa Cruz Biotechnology	CAS 659-22-3	4,4-trans-dihydroxystilbene