Table 2. Animal models of ZIKV infection in non-pregnant female genital tract.

Authors	Animal model	Inoculation route	Female genital tropism	Positive biological fluids
Osuna et al. 52	Rhesus and Cynolmogus Monkeys	Subcutaneous	Vagina Cervix Uterus Ovary	Blood Urine Salive Cervical-vaginal lavage
Hirsch et al. 59	Rhesus Monkeys	Subcutaneous	Uterus Vagina	Blood Urine
Haddow et al. 57	Rhesus and Cynolmogus Monkeys	Vaginal Retal	NI	Blood
Carroll et al. 41	Rhesus Monkeys	Vaginal Subcutaneous	Vagina Cervix Uterus Ovary	Blood Urine Cervical-vaginal lavage
Dowall et al. 38	WT 129Sv/Ev and A129 type I INF-deficient mice	Subcutaneous	Ovary	Blood
Duggal et al. 40	IFN α/β and -γ receptor-knockout AG129 mice	Vaginal Subcutaneous Sexual	Ovary Ovarian follicles	Blood
Tang et al. 55	AG129 and LysMCre+IFNARfl/fl C57BL/6 mice	Vaginal	Vagina	Serum
Broughton et al. 56	C57BL/6 mice	Subcutaneous	Ovary	Serum
Hastings et al. 58	WT, Axl -/-, Mertk -/- , Axl -/- Mertk -/-, and Axl -/- Tyro3 -/- mice	Subcutaneous Vaginal Intracraneal	Vagina	NI
Khan et al. 53	WT mice	Vaginal	Vagina	NI
Scott et al. 61	WT C57BL/6 mice	Subcutaneous	Vagina Cervix Uterine horns Ovary	Serum
Winkler et al. 60	Ifnar1 -/- and Rag -/- mice	Sexual	Vagina	Plasma
Caine et al. 28	Ifnlr1−/−, Ifnar1−/−WT and WT C57BL/6J mice	Vaginal	Vagina Cervix Uterus	NI
Caine et al. 62	WT, congenic CD8−/− and TCRβδ−/− C57BL/6 mice	Subcutaneous	Ovary	Serum

NI: not informed; WT: wild type