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. 2020 Feb 3;7(2):e676. doi: 10.1212/NXI.0000000000000676

Figure 2. Increased reactivity to sialic acid–terminated glycan epitopes Neu5Ac and Neu5Gc in patients with MS.

Figure 2

Recognition of α(2–8)Neu5Ac, α(2–3)Neu5Gc, and Galα1-3Galβ1-4GlcNAcβ carbohydrate structures by sera and CSF. patients with MS from discovery cohort I (A–C) and independent cohort II (D and E) compared with patients with other neurologic diseases NIND and OIND as screened by suspension array. Each dot represents an individual patient. Bar represents median. Significant values are reported using 1-way ANOVA, followed by Tukey multiple comparison test. *p < 0.05; **p < 0.01, ***p < 0.001. ANOVA = analysis of variance; Neu5Ac = N-acetylneuraminic acid; Neu5Gc = N-glycolylneuraminic acid; NIND = noninflammatory neurologic disease; OIND = other inflammatory neurologic disease; RFU = relative fluorescence unit.