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. 2020 Feb 3;7(2):e676. doi: 10.1212/NXI.0000000000000676

Figure 3. High vs low IgG reactivities to Neu5Ac and Neu5Gc epitopes in relation to MS clinical disease severity and activity.

Figure 3

Patients with MS were stratified by means of their high IgG reactivities to Neu5Ac and Neu5Gc epitopes (above median vs below median). (A) Above- and below-median groups were compared with regard to the EDSS score and (B) clinical disease activity as defined by having a relapse or being in remission during the time of blood and CSF sampling. Each dot represents an individual patient. SEM is depicted. Statistical analysis was performed via the (A) Mann-Whitney test and (B) Fisher exact test. EDSS = expanded disability status score; IgG = immunoglobulin G; Neu5Ac = N-acetylneuraminic acid; Neu5Gc = N-glycolylneuraminic acid; ns = non significant; SEM = standard error of the mean.