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. 2020 Feb 27;13:1787–1795. doi: 10.2147/OTT.S238920

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© 2020 Li and Liu.

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Schematic diagram showing the current understanding of the role of PGAM1 in cancer cells and the research directions of PGAM1-targeted drugs. The role of PGAM1 in cancer proliferation has mainly focused on its glycolytic functions. Most small molecular compounds such as PGMI-004A usually have a significant effect on cancer proliferation. The genetic inhibitors such as siRNA and shRNA can influence both proliferation and invasion, respectively. The role of PGAM1 in cancer invasion and metastasis was newly found to be mainly associated with non-glycolytic molecules and pathways. Therefore, a PGAM1-targeted drug to inhibit invasion and metastasis should be developed from the non-glycolytic direction.