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. 2020 Jan 31;93(1):12–22. doi: 10.15386/mpr-1422

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Structure of reactive oxidative molecules in mitochondrion. Disruption of chondrocytes by nitric oxide induced inhibition is involved in chondrocyte functional compromise. Nitric oxide (NO⁻) is released with several pro-inflammatory factors by synovial cells as a result of inflammatory transition. The nuclear transcription factor (NF-t) involved in the upregulation of several inflammatory genes is an important factor for the ROS/RNS induced inflammatory transition of synovial membrane, mainly by NO⁻ related TNF-α and IL-1 induction damage of mitochondrial DNA.