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. Author manuscript; available in PMC: 2020 Mar 2.
Published in final edited form as: Mol Carcinog. 2018 Aug 10;57(11):1664–1671. doi: 10.1002/mc.22879

Figure 2. VEGFR2+ tumor-derived endothelium inhibits M1programming of naive macrophages.

Figure 2

(A) Naive RAW macrophages were cultured with or without SVR endothelium and NO was quantified in the culture supernatant at the indicated time intervals. (B) RAW macrophages were cultured with SVR cells and were stimulated as indicated and NO levels were quantified in the culture supernatant at the indicated time intervals. Shown are the mean levels of NO (μM)±SEM from three independent experiments. Statistical analysis was conducted using a two-tailed paired t-test with 95% confidence intervals (*p<0.05; **p<0.01).