Table 2.

The Results of Mixed-Effects Modeling to Fit MRI Volumetric Data Using Age

Brain Areas	Intercept (mL)	β (mL)	SE (mL)	Rate (%/Year)	P value
Left hemisphere	618.5	−7.64	1.163	−1.24	0.001
Right hemisphere	612.8	−12.98	0.987	−2.12	< 0.001
Corpus callosum	28.4	−0.25	0.034	−0.87	< 0.001
Cerebellar WM	19.7	0.02	0.183	0.08	0.94
Midbrain	9.76	−0.11	0.018	−1.1	0.001
Pons	16.89	−0.22	0.031	−1.31	< 0.001
Medulla	5.84	−0.06	0.005	−1.03	< 0.001
Left hippocampus	3.52	−0.12	0.018	−3.35	0.001
Right hippocampus	2.87	−0.22	0.022	−7.82	< 0.001
Left amygdala	1.69	−0.06	0.010	−3.73	0.001
Right amygdala	1.76	−0.14	0.013	−7.73	< 0.001
Lateral ventricles	39.3	5.36	0.578	13.65	< 0.001
Third ventricle	3.00	0.12	0.021	4.14	0.001
Fourth ventricle	2.85	0.01	0.020	0.21	0.76
Whole brain WMHs	13.5	2.93	0.392	21.71	< 0.001

Notes: The annual rate of change is calculated based on the intercept, the fitted value for the 2010 visit.

Abbreviations: WM, white matter; WMHs, white matter hyperintensities.