Fig. 1.

Mucosal BCG vaccination provides enhanced protection against M. tb infection in the lung. Mice immunised with BCG via IN or ID route were challenged 6 weeks later with M. tb via aerosol. Four weeks post-challenge, CFU were enumerated in lungs and spleen. Individual log₁₀ CFU counts are shown with bars indicating mean ± standard error of the mean (SEM) (n ≥ 7). One-way ANOVA with Tukey’s post-test for significance; ****P < 0.0001; **P < 0.01. Data are representative of one of two independent experiments