Table 2.

EBMT criteria for severity grading of a suspected SOS/VOD in adults

	Milda	Moderatea	Severe	Very severe MOD/MOFb
Time since first clinical symptoms of SOS/VODc	>7 days	5–7 days	≤4 days	Any time
Bilirubin (mg/dL)	≥2 and <3	≥3 and <5	≥5 and <8	≥8
Bilirubin (μmol/L)	≥34 and <51	≥51 and <85	≥85 and <136	≥136
Bilirubin kinetics			Doubling within 48 h
Transaminases	≤2 × normal	>2 and ≤5 × normal	>5 and ≤8 × normal	>8 × normal
Weight increase	<5%	≥5% and <10%	≥5 % and <10%	≥10%
Renal function	<1.2 × baseline at transplant	≥1.2 and <1.5 × baseline at transplant	≥1.5 and <2 × baseline at transplant	≥2 × baseline at transplant or others signs of MOD/MOF

Patients belong to the category that fulfills two or more criteria. If patients fulfill two or more criteria in two different categories, they must be classified in the most severe category. Patient’s weight increase ≥5% and <10% is considered by default as a criterion for severe SOS/VOD, however if patients do not fulfill other criteria for severe SOS/VOD, weight increase ≥5 % and <10% is therefore considered as a criterion for moderate SOS/VOD

^aIn the case of the presence of two or more risk factors for SOS/VOD, patients should be in the upper grade

^bPatients with multiorgan dysfunction must be classified as very severe

^cTime from the date when the first signs/symptoms of SOS/VOD began to appear (retrospectively determined) and the date when the symptoms fulfilled SOS/VOD diagnostic criteria