Table 3.

Risk factors for SOS/VOD

Transplant-related factors

Unrelated donor

HLA-mismatched donor

Non-T-cell depleted transplant

Myeloablative conditioning regimen

Oral or high-dose busulfan-based regimen

High-dose TBI-based regimen

Second HSCT

Patient and disease related factors

Older age

Karnofsky score below 90%

Metabolic syndrome

Female receiving norethisterone

Advanced disease (beyond second CR or relapse/refractory)

Thalassemia

Genetic factors (GSTM1 polymorphism, C282Y allele, MTHFR 677CC/1298CC haplotype)

Hepatic related

Transaminases > 2.5 ULN

Serum bilirubin > 1.5 ULN

Cirrhosis

Active viral hepatitis

Abdominal or hepatic irradiation

Previous use of gemtuzumab ozogamicin or inotuzumab ozogamicin

Hepatotoxic drugs

Iron overload

HLA human leukocyte antigen, TBI total body irradiation, ULN upper limit of normal