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. 2020 Feb 25;8:133. doi: 10.3389/fbioe.2020.00133

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Copyright © 2020 Kim, Lee, Niidome, Komohara, Lee and Park.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Histogram plots of the fluorescence intensities showing cellular uptake of curcumin (orange), P-cGNS (blue), R-cGNS (green), and R/P-cGNS (pink) at a concentration of 25 μM curcumin. (B) The mean fluorescence intensities of different curcumin treatment groups with regard to the background level of untreated cells (black). Error bars represent the mean ± SD (n = 3) (***p < 0.001 vs. R-cGNS; n.s., no significant difference, P-cGNS vs. R/P-cGNS). (C) Confocal images of different curcumin treatment groups in B16-BL6 cells.