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. 2020 Mar 2;10:3832. doi: 10.1038/s41598-020-60754-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The permeabilities of the studied SC lipid models composed either of Cer (black), or 1-deoxy-Cer (blue), or 3-deoxy-Cer (dark blue), or N-Me-Cer (orange), along with LIG, Chol, and CholS. (A) Water loss; (B) permeation profile for TH; (C) the flux of TH; (D) permeation profile for IND; (E) the flux of IND; (F) electrical impedance. Data are presented as the means ± standard error of the mean (SEM), n = 5–16. The asterisks show statistically significant differences against the Cer-containing sample (p <0.05).