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. 2019 Dec 10;122(2):245–257. doi: 10.1038/s41416-019-0662-8

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© The Author(s), under exclusive licence to Cancer Research UK 2019

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Fig. 3 — Replacement of PIs-MUFA with PIs-PUFA occurs in invasive cancer cells and is recognised as PI(18:0/20:3) accumulation. a Inter-individual correlation of PIs with different FA compositions in invasive cancer cells. Red and blue circles indicate a positive and negative correlation, respectively. The circled values show the correlation coefficient of each combination, which is also represented by circle size. b Representative histological mapping and the corresponding H&E staining of invasive cancer cells and their surrounding stroma. Cancer cells are encircled by a yellow dotted line in H&E staining. “N” indicates a necrotic region. Relative intensity of ion signals is represented by an RGB scale. Scale bar (white): 50 μm. c Correlation of PIs-MUFA and PIs-PUFA in invasive cancer cells. Triangles and circles indicate individual lesions of invasive cancer cells. The presence of PI(18:0/20:3) accumulation in cancer cells is indicated as a purple triangle. d Comparison of the intensities of invasive cancer cells between the presence and absence of PI(18:0/20:3) accumulation. White and black circles indicate individual lesions for the presence or absence of PI(18:0/20:3) accumulation in cancer cells, respectively. * indicates a statistically significant difference in the comparison between normal and DCIS. Two-way ANOVA with Sidak’s post hoc multiple comparisons test. **p < 0.01; ***p < 0.001; ****p < 0.0001.