TABLE 6.
Systems for incorporation of nucleic acids into electrospun nanofibers, and their designed use.
| Nucleic acid | Nanofiber material | Purpose | References |
| Plasmid (β-galactosidase gene) | Poly (lactic-co-glycolic acid) + poly (lactic-co-glycolic acid)/polyethylene glycol | Simulating gene delivery | Luu et al., 2003 |
| Plasmid (eGFP gene) | Polycaprolactone/polyethylene glycol | Simulating gene delivery | Saraf et al., 2010 |
| Poly (DL-lactide)-poly (ethylene glycol) | Simulating gene delivery | Yang et al., 2011 | |
| Polycaprolactone | Simulating gene delivery | Ceylan et al., 2013 | |
| Poly(1,4-butanediol diacrylate-co-4-amino-1-butanol) end-capped with 1-(3-aminopropyl)-4-methylpiperazine | Simulating gene delivery | Li et al., 2013 | |
| Plasmid (β-galactosidase/GFP genes) | Polylactic acid/polyethylene glycol/poly (lactic-co-glycolic acid) | Simulating gene delivery | Liang et al., 2005 |
| Plasmids (vascular endothelial growth factor/fibroblast growth factor genes) | Poly (DL-lactide)-poly (ethylene glycol) | Gene delivery (regeneration of blood vessels) | Chen et al., 2013 |
| MicroRNA (miRNA-222) | Polycaprolactone-co-ethyl ethylene phosphate | Gene silencing of NTF3 | Nguyen et al., 2017 |
| MicroRNAs (miRNA-219, miRNA-338) | Polycaprolactone | Gene silencing of PDGFR-α, Sox6, Hes5, FoxJ3, ZFP238 | Diao et al., 2015 |
| siRNA | Polycaprolactone or polycaprolactone/polyethylene glycol | Gene silencing of GAPDH | Cao et al., 2010 |
| Polycaprolactone-co-ethyl ethylene phosphate | Gene silencing of GAPDH | Rujitanaroj et al., 2011 |