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Characteristics of the M. tuberculosis spontaneous TP053 resistant mutants.
| M. tuberculosis strains | Concentration of isolation of TP053 resistant colonies (μg/ml) |
Mutation in mrx2 |
Mutation in Rv0579 (aa change) | MIC to TP53 (μg/ml) | |
| On genome | On plasmid | ||||
| M. tuberculosis/pSODIT/mrx2 | – | – | – | – | 0.125 |
| 2466.3 mutant | 0.5 (4× MIC) | No | No | C718G (L240V) | 2.5 (20× MIC) |
| 2466.4 mutant | 1 (8× MIC) | No | No | C718G (L240V) | 2.5 (20× MIC) |
