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. 2020 Feb 25;10:212. doi: 10.3389/fonc.2020.00212

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Copyright © 2020 Li, Dong, Yang, Song, Mou and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Xenograft OSCC mouse models. (A–D) An ectopic mouse model of OSCC. (A) OSCC-BD cells overlapped and lost contact inhibition. (B) HE staining showed that OSCC-BD cells had malignant characters. (C) The nude mice were subcutaneously injected with OSCC-BD cells. Tumor formation was observed, and neoplasms were about 1.0± 0.2 cm in size. (D) HE staining showed the neoplasm was typical squamous cell carcinoma. Scale bars, 100 μm (A) and 50 μm (B). Reproduced and modified with permission (110). Copyright © 2015, Springer Nature. (E–H) An orthotopic mouse model injected into the lateral border of the tongue of non-obese diabetes–severe combined immune deficiency (NOD-SCID) mice via HSC-3 cells. The HSC-3 bearing tumors have (E,F) ulcers, (G) neural, and (H) vascular invasion (arrows). Scale bars, 0.2 cm (E), 400 μm (F), and 200 μm (G,H). Reproduced and modified with permission (111). Copyright © 2018, Springer Nature.