| Athymic nude mouse |
Homozygous nu/nu mutant mice; spontaneous deletion in the Foxn1 gene |
Lack of functional T lymphocytes |
18 months to 2 years |
Hairless, naked, and athymic |
| SCID mouse |
A spontaneous mutation in C.B-I7Icr (C.B17) mice termed “SCID” (Prkdcscid), or express the Rag1null or Rag2null mutations |
Lack of mature T and B lymphocytes |
Above 1 year |
“leaky,” can generate a certain degree of functional T and B cells with the increase of age |
| NOD-SCID mouse |
Backcross the SCID mutation onto NOD mouse strain background |
Lack of functional T and B lymphocytes. Lower NK cell activity, reduce levels of macrophage activation, abnormal DCs development and an absence of hemolytic complement |
8 to 9 months |
Less “leaky”; has spontaneous lymphoma |
| NOD-PrkdcscidIL2rgnull mouse |
NOD genetic background, Prkdcscid, and a targeted mutation in the IL2-receptor common gamma chain gene (IL2rgnull) |
Lack T, B, and NK cells and have functionally impaired DCs and macrophages |
1.5 years |
No B lymphocyte leakage |
