Table 4.
Xenograft OSCC mouse models.
| Classification | Cell lines / tissue source | End point | Mouse strains | Ref. |
|---|---|---|---|---|
| PDX | Patients with HNSCC | Xenografts reached 100 mm3 to 200 mm3 | NSG mice | (130) |
| CDX | UM-SCC47 cells (1 × 106 cells) | Xenografts reached 100 mm3 to 200 mm3 | Nude-Foxn1null mice | (130) |
| CDX;Orthotopic | CAL27-DsRed cells (0.5 × 106 cells in 40 μl per tongue) UMSCC2-DsRed cells (0.5 × 106 cells in 40 μl per tongue) |
CAL27 tumors grew up to 25 ± 6 mm3 by day 31 UMSCC2 tumors grew up to 20 ± 5 mm3 by day 31 | Nude mice (NCr nu/nu) | (131) |
| PDX; Ectopic (bilaterally subcutaneous) | Three patients with HNSCC | A volume of 2,000 mm3 | SCID mice | (132) |
| PDX; Ectopic (in the flank) | HNSCC patients (25 mg of tumor/mouse) | A volume of 1 cm maximum diameter | NOD/SCID gamma mice | (133) |
| PDX; Ectopic (subcutaneous) | OSCC of right retromolar trigone, T3N0M0 and tongue—SCC, T1N2b | About 30 days | SCID mice | (134, 135) |
| PDX; Ectopic (subcutaneously on the flank) | Two patients with oral cancer T4N0M0 and T2N2M0 | A volume of 1,000–1,500 mm3 | Nude mice | (136) |