Table 1.
Percentage cell viability of MIN6 cells in the presence of sesamol and simvastatin as obtained from MTT assay
Treatment drug | Cell viability (%) |
---|---|
Simvastatin (70 μM) | 51.55 ± 1.91 |
Sesamol (7.8 μM) + simvastatin (70 μM) | 77.61 ± 6.24* |
Sesamol (15.6 μM) + simvastatin (70 μM) | 87.42 ± 5.61** |
Sesamol (31.25 μM) + simvastatin (70 μM) | 84.76 ± 6.76** |
Sesamol (62.5 μM) + simvastatin (70 μM) | 54.09 ± 0.41 |
All the values are expressed as mean ± SEM, where *p < 0.05 compared to simvastatin, **p < 0.05 compared to simvastatin. Data were compared with each other by one-way ANOVA followed by Tukey’s post hoc analysis using Prism version 6.01 Demo version (Graph Pad Inc., La Jolla, CA, USA). Statistical values are F (DFn, DFd): F (4, 10) = 12.2, p = 0.0007. IC50 of sesamol is 2134 ± 8.41 μM, IC50 of simvastatin is 70.05 ± 2.34 μM