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. 2020 Mar 2;11:1146. doi: 10.1038/s41467-020-14948-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Immunoprecipitation analysis of linear ubiquitination of STAT1 in the lung, spleen, and liver tissues from Rbck1^+/+ or Rbck1^+/− mice. b Western blot analysis of pY-STAT1 in the lung tissues from Rbck1^+/+ or Rbck1^+/− mice administrated with mIFNβ (1500 IU/g, i.p.) for 8 h. c RT-qPCR analysis of the representative ISGs (Ifit1, Rsad2, and Trim25) mRNA in the liver tissues from Rbck1^+/+ or Rbck1^+/− mice administrated with mIFNβ as b. d RT-qPCR analysis of a representative ISG (Ifit1) mRNA in the spleen, heart, and kidney tissues from Rbck1^+/+ or Rbck1^+/− mice administrated with mIFNβ as b. e RT-qPCR analysis of VSV viral RNA in the liver, spleen, and lung tissues from Rbck1^+/+ or Rbck1^+/− mice infected with VSV (1 × 10⁸ PFU per gram body mouse, i.p.) for 24 h. **p < 0.01 and ***p < 0.001 (two-tailed unpaired Student’s t test). All graphs show the mean ± SEM for six individual mice (c–e). Data are representative of three independent experiments (a, b).