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Mitoxantrone flux across PBMEC grown on permeable inserts. Mitoxantrone transport in apical-to-basolateral (AB) (circles) or basolateral-to-apical (BA) (squares) under (A) static media or (B) when exposed to high flow (550 µL/min) for 48 hours with associated apparent membrane permeability (Papp) values in the AB or BA directions (C). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 and ****p ≤ 0.0001. n = 16 for static and dynamic, in 4 independent experiments.
