Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 2;10:3810. doi: 10.1038/s41598-020-60761-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Transcriptomic profiling of human PBMCs during EV-A71 infection. Primary human PBMCs (n = 4) were infected with mild, moderate, severe and heat-inactivated EV-A71 isolates at MOI 5, and harvested at 0, 6, 12 and 24 hpi for transcriptomic analysis by RNA-seq. Results of infected conditions were compared to heat-inactivated control, and the log₂-(fold change) values were analysed in Ingenuity Pathway Analysis (IPA). (a,b) Overall changes of significant (a) differentially expressed genes (DEGs) and (b) canonical pathways identified by IPA over time and in different isolates. (c) Heat-map showing normalised log₂-(fold change) values of the common DEGs in all infected conditions of 6, 12 and 24 hpi. (d) Significant canonical pathways determined by IPA from the common DEGs in (c) (*p < 0.05; ***p < 0.001). (e) Heat-map showing the activation z-score values of the top four canonical pathways as determined by IPA.