Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 2;10:3810. doi: 10.1038/s41598-020-60761-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Differences in transcriptomic profiles of human PBMCs infected with different EV-A71 isolates. Primary human PBMCs (n = 4) were infected with mild, moderate, severe and heat-inactivated EV-A71 isolates at MOI 5, and harvested at 0, 6, 12 and 24 hpi for transcriptomic analysis by RNA-seq. Results of infected conditions were compared to heat-inactivated control, and the log₂-(fold change) values were analysed in Ingenuity Pathway Analysis (IPA). (a,b) Venn diagrams illustrating the number of significant (a) differentially expressed genes (DEGs) and (b) canonical pathways of the different EV-A71 isolates at 6, 12 and 24 hpi. (c) Heat-map showing the activation z-scores of the top 10 canonical pathways at 24 hpi as determined by IPA. Asterisks indicate the significance of the pathway in respective isolates. (d) Heat-map showing normalised log₂-(fold change) values of the genes involved in TREM-1 signalling pathway at 24 hpi. Grey boxes indicate no values. (*p < 0.05; **p < 0.01; ***p < 0.001).