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. 2020 Mar 2;10:3808. doi: 10.1038/s41598-020-60796-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Bisulfite genomic sequencing of the LINE-1 promoter region in primary uroepithelial cells before and after ODC1 RNA interference. Detailed analyses of LINE-1 promoter CpG methylation status of primary uroepithelial cells (A) and of the same uroepithelial cells after 72 h of treatment with ODC1 RNAi (B). Black, white and grey circles stand for methylated, unmethylated and undefined CpG dinucleotides, respectiely. The graph at the top of the figure depicts a schematic representation of a full-length LINE-1 retroelement with the proportional distribution of all CpG dinucleotides (short ertical strokes) and the open reading frames 1 and 2 (ORF1/2). The CpG rich region analyzed by bisulfite genomic sequencing is highlighted by a square bracket.