Figure 1.

Schematic protocol of the gut-disseminated murine model of candidaemia. Five-week-old female DBA2/J mice were infected intragastrically with 0.2 ml of Candida cells (5 × 10⁶ CFU/ml) on day 0 following 14 d of a low protein diet and 24 h of food deprivation. The mice were provided sterile water containing 200 mg/l of enrofloxacin and 500 mg/l of vancomycin from the time of inoculation until the end of the experiment. Mice were treated intraperitoneally (i.p.) with cyclophosphamide (150 mg/kg of body weight) on days 4, 7, 10, 13, 16, and 19 post-infection.