Fig. 7. P27 overexpression counteracts the effects of HMGA1 in DCM mouse hearts.
Mice received AAV9-HMGA1 and AAV9-P27 injections at 10 weeks after the final STZ injection (n = 12 per group). a Protein levels of P27 in mouse hearts 6 weeks after AAV9-P27 injection (n = 6). b Protein levels of LC3 and P62 in DCM mouse hearts (n = 6). c, d Immunohistochemical staining and quantification results for CD45, CD68 in DCM mouse hearts (n = 5). e Transcription levels of proinflammatory markers in DCM mouse hearts (n = 6). f TUNEL staining and quantification results in mouse hearts (n = 5). *P < 0.05 vs. the AAV9-NC-CON group.