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. 2019 Dec 10;122(2):209–220. doi: 10.1038/s41416-019-0658-4

Fig. 6. MFN1 influences HCC cells proliferation, invasion and migration via metabolic reprogramming.

Fig. 6

a–c Proliferation assay (a) and plate clone formation assay (c) showed that 2-DG inhibited the proliferation of sh-MFN1 HepG2 cells. But 2-DG did not affect proliferation capacity in OE-MFN1 97H cells (b). n = 3, mean ± SEM, ***P < 0.001, **P < 0.01, *P < 0.05. d–i Transwell assay (d, e, f, g) and wound-healing assays (h, i) confirmed that 2-DG could reverse the effect of sh-MFN1 to retrain migration and invasion of HepG2 cells. n = 3, mean ± SEM, ***P < 0.001, **P < 0.01, *P < 0.05.