Table 3.
The diagnostic performance of texture features derived from simutanous18F-FDG PET image and the ADC map for predicting synchronous distant metastasis in pancreatic ductal adenocarcinoma patients.
| Texture feature | M0 group | M1 group | P1 | AUC | 95% confidence intervals | P2 | Optimal cut-off value |
|---|---|---|---|---|---|---|---|
| PET-GLRLM_RLNU | 467 ± 173 | 1391 ± 738 | 0.002 | 0.939 | 0.711–0.998 | <0.0001 | >751 |
| PET-GLRLM_LRHGE | 172 ± 77 | 288 ± 96 | 0.037 | 0.818 | 0.560–0.960 | 0.005 | >120.6 |
| PET-NGLDM_Coarseness | 0.015 ± 0.008 | 0.007 ± 0.003 | 0.037 | 0.803 | 0.543–0.952 | 0.034 | < =0.01 |
| PET-GLZLM_GLNU | 5.4 ± 2.3 | 11.3 ± 6.8 | 0.020 | 0.848 | 0.595–0.973 | 0.0004 | >8.3 |
| ADC-HISTO_Skewness | −0.02 ± 0.59 | 0.72 ± 0.80 | 0.048 | 0.795 | 0.534–0.948 | 0.001 | >0.14 |
| ADC-HISTO_Kurtosis | 3.32 ± 1.16 | 5.25 ± 2.01 | 0.048 | 0.803 | 0.543–0.952 | 0.008 | >3.84 |
| ADC-GLRLM_LRE | 36 ± 10 | 66 ± 24 | 0.007 | 0.894 | 0.650–0.989 | <0.0001 | >42.98 |
| ADC-GLRLM_SRHGE | 786 ± 51 | 654 ± 131 | 0.048 | 0.803 | 0.543–0.952 | 0.006 | < =691 |
| ADC-GLRLM_LRLGE | 0.008 ± 0.002 | 0.019 ± 0.009 | 0.005 | 0.879 | 0.631–0.984 | <0.0001 | >0.012 |
| ADC-GLRLM_LRHGE | 0.15E+6 ± 0.04E+6 | 0.28E+6 ± 0.10E+6 | 0.007 | 0.894 | 0.650–0.989 | <0.0001 | >0.18E+6 |
| ADC-GLRLM_GLNU | 227 ± 96 | 442 ± 142 | 0.003 | 0.924 | 0.690–0.996 | <0.0001 | >269.4 |
| ADC-GLRLM_RLNU | 30 ± 8 | 45 ± 9 | 0.005 | 0.909 | 0.670–0.993 | <0.0001 | >32.6 |
| ADC-GLRLM_RP | 0.212 ± 0.023 | 0.165 ± 0.033 | 0.007 | 0.879 | 0.631–0.984 | <0.0001 | <0.18 |
| ADC-GLZLM_LZE | 1.53E+6 ± 1.67E+6 | 9.50E+6 ± 8.71E+6 | 0.010 | 0.879 | 0.631–0.984 | <0.0001 | >4.62E+6 |
| ADC-GLZLM_LZLGE | 362 ± 395 | 2249 ± 2061 | 0.010 | 0.879 | 0.631–0.984 | <0.0001 | >1094.1 |
| ADC-GLZLM_LZHGE | 0.65E+10 ± 0.70E+10 | 4.01E+10 ± 3.68E+10 | 0.010 | 0.879 | 0.631–0.984 | <0.0001 | >1.95E+10 |
| ADC-GLZLM_ZP | 0.0016 ± 0.0017 | 0.0006 ± 0.0004 | 0.050 | 0.795 | 0.534–0.948 | 0.010 | < =0 |
ADC, apparent diffusion coefficient; AUC, area under receiver operating characteristic (ROC) curve; FDG, fluorodeoxyglucose; M0, no synchronous distant metastasis; M1, with synchronous distant metastasis; NA, not applicable; P1, P-value for independent- samples Mann-Whitney U-test, indicates p-value is significant <0.05; P2, p-value for AUC, indicates P-value is significant <0.05; PET, positron emission tomography; 95% CI, 95% confidence interval; GLRLM, Gray level run length matrix; GLZLM, Gray level zone length matrix; SRHGE, Short-nun high gray-level emphasis; GLNU, Gray-level non-uniformity; RLNU, Run length non-uniformity; LZE, Long-zone emphasis; NGLDM, Neighborhood gray-level different matrix; SZHGE, Short-zone high gray-level emphasis; LZHGE, Long-zone high gray-level emphasis.