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Distinct effects of CD47 deficiency on peroxisome proliferator activated receptor alpha (PPARα and sirtuin 1 (SIRT1) expression between mice fed LFD vs. HFD. Relative mRNA expression levels of PPARα (A) and SIRT1 (B) were quantified by real-time PCR and normalized to β-actin (n = 4 per group). Data are presented as mean ± SD. *p < 0.05; **p < 0.01; ***P < 0.001; and ****P < 0.0001.
