Figure 1.

Tumor-Intrinsic Mechanisms of Immune Evasion and Relapse. This cartoon summarizes the features of the three modalities of leukemia immune evasion and relapse after allo-HCT better characterized to date. Chromosomes indicate the HLA haplotype homo- or hetero-zygosity, showing in cyan the donor-recipient shared haplotype and in red the patient-specific incompatible haplotype. The padlock symbolizes epigenetic silencing of the HLA class II loci. On the cell surface, HLA class I molecules are shown as heterodimers of HLA and beta-2-microglobulin (in yellow), HLA class II as dimers of two transmembrane single-chain HLA molecules, and inhibitory ligands as green homodimers.