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. 2020 Feb 25;11:70. doi: 10.3389/fpsyt.2020.00070

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Copyright © 2020 Ramirez-Mahaluf, Rozas-Serri, Ivanovic-Zuvic, Risco and Vöhringer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinician-rated depressive symptoms at the 10^th day adding medication to TSD (A) and the funnel plot of included studies (B). Clinician remission at the 3^rd month (C) and the funnel plot of included studies (D). TSD, Total sleep deprivation; MED, Medication; CI, Confidence interval; SD, Standard deviation; N, Sample size; R, Remission; NR, No remission; Tests of heterogeneity, I² and Q statistic were included. REML, Restricted maximum likelihood.