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. 2020 Feb 25;14:7. doi: 10.3389/fnint.2020.00007

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Copyright © 2020 Neul, Skinner, Annese, Lane, Heydemann, Jones, Kaufmann, Glaze and Percy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathway enrichment shows significant enrichment in metabolic pathways related to amino acid metabolism. (A) The impact on a pathway (Pathway Impact) for a given KEGG pathway is shown on the x-axis, and the −log(p) of the uncorrected p-value is presented on the y-axis. The dashed horizontal red line represents the p < 0.05 cutoff after FDR correction. The pathways that are significant (FDR < 0.05) are labeled. (B) MSEA overrepresentation analysis displaying the top 10 enriched pathways. The length of the bar is the fold enrichment of the pathway with the scale presented at the bottom. The numbers indicated the raw p-value for enrichment.