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. 2020 Feb 25;11:137. doi: 10.3389/fneur.2020.00137

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Copyright © 2020 Ren, Gao, Qiu, Jiang, Zhang, Zhang, Wang, Zhang, Wang and Nie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The alpha-diversity and beta-diversity indices of the fecal microbiome in the PD-MCI, PD-NC, and health group. (A) Box plots depict differences in the fecal microbiome diversity indices among three groups according to the Chao 1 index, PD whole tree index, Shannon index and Simpson index based on the OTU counts. Each box plot represents the median, interquartile range, minimum, and maximum values. (B) Unweighted and weighted ANOSIMs Unifrac analysis based on the distance matrix of UniFrac dissimilarity of the fecal microbial communities in the three groups. Respective ANOSIM R values show the community variation between three groups and significant P values are indicated. The axes represent the two dimensions explaining the greatest proportion proportion of variance in the communities. OTU, operational taxonomic unit, ANOSIM, analyses of similarities.