Fig. 6.

Combination of cell sheet technology with bone and PDL scaffolds to regenerate cementum-PDL-alveolar bone. (A) Fabrication scheme showing the combination of PDL and bone compartments with a dentin slice. The bone and PDL layers were fabricated using fused deposition and electrospinning, respectively. (B) SEM image of the biphasic scaffold showing the fusion of the electrospun fibers onto the fused deposition component. (C) Subcutaneously transplanted the construct to induce periodontal regeneration in vivo. (D) PDL-like and (E) cementum-like tissues formation after transplantation for eight weeks. (F) CaP was coated on the PCL fused deposition compartment. (G) The CaP-coated scaffold enhanced bone formation. Adapted with permission from Refs. [88,166].