Table I.
Fraction time in contact for residue pairs that were rescued or missing in AYEdes
| Contact group | AYEwt | AYEdes | Status | ||||
|---|---|---|---|---|---|---|---|
| Contact pair | 25°C | 100°C | Contact pair | 25°C | 100°C | ||
| α1–α2 | Asn18–Leu59 | 0.00 | 0.01 | Phe18a–Leu59 | 0.99 | 0.98 | FRb |
| Leu19– Val55 | 0.01 | 0.87 | Leu19–Phe55a | 0.98 | 0.96 | FR | |
| Leu19– Phe58 | 0.99 | 1.00 | Leu19– Met58a | 0.18 | 0.05 | Mb | |
| Gln21–Phe58 | 0.96 | 0.70 | Ala21a–Met58a | 0.00 | 0.00 | M | |
| Leu22–Ala54 | 0.00 | 0.43 | Leu22–Trp54a | 0.99 | 0.99 | FR | |
| Leu22–Val55 | 1.00 | 0.93 | Leu22–Phe55a | 1.00 | 1.00 | FR | |
| Leu22–Leu59 | 1.00 | 0.74 | Leu22–Leu59 | 0.38 | 0.68 | M | |
| α1–β-sheet | Gln15–Val9 | 1.00 | 0.91 | Gln15–Val9 | 1.00 | 1.00 | FR |
| Gln15–Ala65 | 0.14 | 0.20 | Gln15–Pro65a | 0.99 | 0.99 | FR | |
| Leu19–Ala43 | 1.00 | 0.91 | Leu19–Val43a | 1.00 | 1.00 | FR | |
| Leu20–Ser35 | 0.99 | 0.66 | Leu20–Pro35a | 0.00 | 0.05 | M | |
| Leu20–Pro36 | 1.00 | 0.80 | Glu20a–Pro36 | 1.00 | 1.00 | FR | |
| Glu23–Pro36 | 0.65 | 0.03 | Ala23a–Pro36 | 1.00 | 0.99 | FR | |
| α2–β-sheet | Val52–Ile68 | 0.99 | 1.00 | Val52–Val68a | 0.42 | 0.32 | M |
| Val55–Ile8 | 0.67 | 0.28 | Phe55a–Ile8 | 1.00 | 1.00 | FR | |
| Val55–Val45 | 0.88 | 0.75 | Phe55a–Ile45a | 1.00 | 1.00 | FR | |
| Lys56–Leu6 | 1.00 | 0.94 | Leu56a–Phe6a | 1.00 | 1.00 | FR | |
| Lys56–Ile68 | 1.00 | 0.97 | Leu56a–Val68a | 0.94 | 0.72 | M | |
aResidues mutated in AYEdes relative to AYEwt.
bFR = Fully rescued, M = Missing.